It was not immediately clear what was behind the explosions. Venezuela's government, the Pentagon and White House did not immediately respond to requests for comment.
People in various neighborhoods rushed to the streets. The southern area of the city, near a major military base, was without electricity.
A CNN team witnessed several explosions, with the first blast recorded at approximately 1:50 a.m. local time. Some areas of the city were without power, and journalists in the Venezuelan capital could hear sounds of aircraft after the explosions.
This comes as the U.S. military has been targeting, in recent days, alleged drug-smuggling boats. Trump on Monday said the United States hit and destroyed a docking area for alleged Venezuelan drug boats. The Republican leader would not say if it was a military or CIA operation or where the strike occurred.
On Friday, Venezuela said it was open to negotiating an agreement with the United States to combat drug trafficking. President Nicolás Maduro also said in a pretaped interview aired Thursday that the U.S. wants to force a government change in Venezuela and gain access to its vast oil reserves through the monthslong pressure campaign that began with a massive military deployment to the Caribbean Sea in August.